Covaris is a biological sample preparation technology company whose solutions are used for DNA and RNA processing prior to next-generation sequencing, or NGS. Precise and reproducible sample preparation is one of the most important prerequisites for obtaining high-quality sequencing data.

Covaris instruments, reagents, and specialized consumables help standardize laboratory workflows, preserve sample integrity, and reduce the risk of errors that could affect results.

Adaptive Focused Acoustics Technology

Covaris solutions are based on the patented Adaptive Focused Acoustics® (AFA®) technology. It uses precisely controlled and focused ultrasonic energy to process biological material uniformly and reproducibly within a closed sample vessel.

The AFA process takes place without direct contact with the sample and under controlled temperature conditions. This helps prevent overheating, contamination, and unnecessary sample loss while preserving nucleic acid quality and complexity.

DNA and RNA Shearing for NGS

Covaris AFA technology provides precise mechanical shearing of DNA and RNA for sequencing library preparation. Depending on the selected instrument, vessel, and protocol, fragments of a defined size with a narrow and uniform distribution can be obtained.

The main advantages of the technology include:

• high process precision and reproducibility;
• uniform DNA and RNA fragment size distribution;
• minimal GC-content bias;
• controlled temperature and reduced risk of thermal damage;
• processing in a closed vessel without direct contact with the sample;
• reduced risk of cross-contamination and sample loss;
• transferability of protocols between instruments;
• the ability to process both individual samples and large sample batches;
• integration into automated laboratory workflows.

Wide Range of Applications

Covaris sample preparation solutions are suitable for a variety of molecular biology and sequencing workflows:

• DNA and RNA shearing for NGS library preparation;
• whole-genome sequencing;
• germline variant research;
• targeted sequencing;
• FFPE tissue sample processing and biomolecule extraction;
• cell-free DNA, or cfDNA, extraction;
• chromatin shearing and epigenomics research;
• cell lysis;
• proteomics and other biomolecular research applications.

Instruments, Reagents, and Consumables

Covaris offers focused-ultrasonicator instruments designed for different sample volumes and throughput requirements — from single-sample processing to high-throughput and automated laboratory systems.

The product range also includes specialized sample vessels, DNA and RNA shearing kits, sequencing library preparation solutions, FFPE biomolecule extraction kits, and consumables designed for specific laboratory workflows.

Covaris Solutions in Latvia

We help laboratories, research institutions, and specialists in Latvia select the most suitable Covaris instruments, reagents, and consumables for their specific workflows, sample volumes, and research objectives.

Contact us to receive professional advice, technical information, and a customized quotation for Covaris sample preparation solutions.